Open AccessPhosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites
Author(s) -
Manish Goyal,
Adina Heinberg,
Vera Mitesser,
Sofiya Kandelis-Shalev,
Brajesh Kumar Singh,
Ron Dzikowski
Publication year - 2021
Publication title -
msphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.749
H-Index - 39
ISSN - 2379-5042
DOI - 10.1128/msphere.01131-20
Subject(s) - malaria , biology , genome , plasmodium falciparum , histone , antigenic variation , epigenetics , dna , plasmodium (life cycle) , genetics , parasite hosting , virology , evolutionary biology , antigen , gene , immunology , world wide web , computer science
Plasmodium falciparum is the deadliest human parasite that causes malaria when it reaches the bloodstream and begins proliferating inside red blood cells, where the parasites are particularly prone to DNA damage. The molecular mechanisms that allow these pathogens to maintain their genome integrity under such conditions are also the driving force for acquiring genome plasticity that enables them to create antigenic variation and become resistant to essentially all available drugs.