Open AccessSingle-Molecule Dynamics at a Bacterial Replication Fork after Nutritional Downshift or Chemically Induced Block in Replication
Author(s) -
Rogelio Hernández-Tamayo,
Hannah Schmitz,
Peter L. Graumann
Publication year - 2021
Publication title -
msphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.749
H-Index - 39
ISSN - 2379-5042
DOI - 10.1128/msphere.00948-20
Subject(s) - replication (statistics) , minichromosome maintenance , dna replication , microbiology and biotechnology , origin recognition complex , pre replication complex , control of chromosome duplication , replication factor c , fork (system call) , biology , dna , eukaryotic dna replication , biophysics , genetics , computer science , virology , operating system
All cells need to adjust DNA replication, which is achieved by a well-orchestrated multiprotein complex, in response to changes in physiological and environmental conditions. For replication forks, it is extremely challenging to meet with conditions where amino acids are rapidly depleted from cells, called the stringent response, to deal with the inhibition of one of the centrally involved proteins or with DNA modifications that arrest the progression of forks.