Single-Molecule Dynamics at a Bacterial Replication Fork after Nutritional Downshift or Chemically Induced Block in Replication | Zendy

Rogelio Hernández-Tamayo | Zendy; Hannah Schmitz | Zendy; Peter L. Graumann | Zendy

Open Access

Single-Molecule Dynamics at a Bacterial Replication Fork after Nutritional Downshift or Chemically Induced Block in Replication

Author(s) -

Rogelio Hernández-Tamayo,

Hannah Schmitz,

Peter L. Graumann

Publication year - 2021

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00948-20

Subject(s) - dnag , replisome , dnab helicase , primase , dna replication , biology , dna polymerase , microbiology and biotechnology , pre replication complex , control of chromosome duplication , polymerase , eukaryotic dna replication , genetics , dna , helicase , gene , reverse transcriptase , polymerase chain reaction , rna

All cells need to adjust DNA replication, which is achieved by a well-orchestrated multiprotein complex, in response to changes in physiological and environmental conditions. For replication forks, it is extremely challenging to meet with conditions where amino acids are rapidly depleted from cells, called the stringent response, to deal with the inhibition of one of the centrally involved proteins or with DNA modifications that arrest the progression of forks.

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