Open AccessOptimization of Multivalent Gold Nanoparticle Vaccines Eliciting Humoral and Cellular Immunity in an In Vivo Model of Enterohemorrhagic Escherichia coli O157:H7 Colonization
Author(s) -
Javier I. Sanchez-Villamil,
Daniel Tapia,
Alfredo G. Torres
Publication year - 2022
Publication title -
msphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.749
H-Index - 39
ISSN - 2379-5042
DOI - 10.1128/msphere.00934-21
Subject(s) - pathogen , antigen , microbiology and biotechnology , reverse vaccinology , in vivo , escherichia coli , biology , immunity , human pathogen , vaccination , immunogenicity , immune system , immunology , virology , bacteria , biochemistry , genetics , gene , epitope
EnterohemorrhagicE. coli O157:H7 remains an important human pathogen that does not have an effective and safe vaccine available. We have made outstanding progress in the identification of novel protective antigens that have been incorporated into the gold nanoparticle platform and used as vaccines.