Open AccessAcquisition of Host Cytosolic Protein by Toxoplasma gondii Bradyzoites
Author(s) -
Geetha Kannan,
Pariyamon Thaprawat,
Tracey L. Schultz,
Vern B. Carruthers
Publication year - 2021
Publication title -
msphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.749
H-Index - 39
ISSN - 2379-5042
DOI - 10.1128/msphere.00934-20
Subject(s) - toxoplasma gondii , intracellular parasite , biology , cytosol , intracellular , microbiology and biotechnology , vacuole , parasite hosting , protease , cytoplasm , immunology , biochemistry , antibody , enzyme , world wide web , computer science
Chronic infection of humans with Toxoplasma gondii is common, but little is known about how this intracellular parasite obtains the resources that it needs to persist indefinitely inside neurons and muscle cells. Here, we provide evidence that the chronic-stage form of T. gondii can internalize proteins from the cytosol of infected cells despite residing within an intracellular cyst that is surrounded by a cyst wall.