Improved Subtyping of Staphylococcus aureus Clonal Complex 8 Strains Based on Whole-Genome Phylogenetic Analysis | Zendy

Jolene R. Bowers | Zendy; Elizabeth M. Driebe | Zendy; Valérie Albrecht | Zendy; Linda K. McDougal | Zendy; Mitchell E. Granade | Zendy; Chandler C. Roe | Zendy; Darrin Lemmer | Zendy; J. Kamile Rasheed | Zendy; David M. Engelthaler | Zendy; Paul Keim | Zendy; Brandi Limbago | Zendy

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Improved Subtyping of Staphylococcus aureus Clonal Complex 8 Strains Based on Whole-Genome Phylogenetic Analysis

Author(s) -

Jolene R. Bowers,

Elizabeth M. Driebe,

Valérie Albrecht,

Linda K. McDougal,

Mitchell E. Granade,

Chandler C. Roe,

Darrin Lemmer,

J. Kamile Rasheed,

David M. Engelthaler,

Paul Keim,

Brandi Limbago

Publication year - 2018

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00464-17

Subject(s) - clade , biology , genome , subtyping , phylogenetic tree , typing , phylogenetics , lineage (genetic) , genetics , multilocus sequence typing , staphylococcus aureus , whole genome sequencing , monophyly , strain (injury) , evolutionary biology , genotype , gene , bacteria , computer science , programming language , anatomy

Staphylococcus aureus is a major human pathogen worldwide in both community and health care settings. Surveillance forS. aureus strains is important to our understanding of their spread and to informing infection prevention and control. Confusion surrounding the strain nomenclature of one of the most prevalent lineages ofS. aureus , clonal complex 8 (CC8), and the imprecision of current tools for typingS. aureus make surveillance and source tracing difficult and sometimes misleading. In this study, we clarify the CC8 strain designations and propose a new typing scheme for CC8 isolates that is rapid and easy to use. This typing scheme is based on relatively stable genomic markers, and we demonstrate its superiority over traditional typing techniques. This scheme has the potential to greatly improve epidemiological investigations ofS. aureus .

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