Open AccessEstablishment of a Controlled Human Infection Model with a Lyophilized Strain of Shigella sonnei 53G
Author(s) -
Robert W. Frenck,
Michelle Dickey,
Akamol E. Suvarnapunya,
Lakshmi Chandrasekaran,
Robert W. Kaminski,
Kristen A. Clarkson,
Monica McNeal,
Amanda Lynen,
Susan Parker,
Amy Hoeper,
Sachin Mani,
Alan Fix,
Nicole Maier,
Malabi M. Venkatesan,
Chad K. Porter
Publication year - 2020
Publication title -
msphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.749
H-Index - 39
ISSN - 2379-5042
DOI - 10.1128/msphere.00416-20
Subject(s) - medicine , shigella sonnei , shigellosis , vaccination , dosing , ciprofloxacin , shigella , antibiotics , immunology , microbiology and biotechnology , salmonella , biology , bacteria , genetics
Controlled human infection models (CHIMs) are invaluable tools utilized to understand the human response to infection, potentially leading to protective immune mechanisms and allowing efficacy testing of enteric countermeasures, including vaccines, antibiotics, and other products. The development of an improvedShigella CHIM for bothShigella sonnei andShigella flexneri is consistent with international efforts, supported by international donors and the World Health Organization, focused on standardizingShigella CHIMs and using them to accelerateShigella vaccine development. The use of lyophilizedShigella challenge strains rather than plate-grown inoculum preparations is considered an important step forward in the standardization process. Furthermore, the results of studies such as this justify the development of lyophilized preparations for additional epidemiologically importantS. flexneri serotypes, includingS. flexneri 3a andS. flexneri 6.