First IncHI2 Plasmid Carrying mcr-9.1 , bla VIM-1 , and Double Copies of bla KPC-3 in a Multidrug-Resistant Escherichia coli Human Isolate | Zendy

Serena Simoni | Zendy; Marina Mingoia | Zendy; Andrea Brenciani | Zendy; Maria Carelli | Zendy; Maria M. Lleò | Zendy; Giovanni Malerba | Zendy; Carla Vignaroli | Zendy

Open Access

First IncHI2 Plasmid Carrying mcr-9.1 , bla _VIM-1 , and Double Copies of bla _KPC-3 in a Multidrug-Resistant Escherichia coli Human Isolate

Author(s) -

Serena Simoni,

Marina Mingoia,

Andrea Brenciani,

Maria Carelli,

Maria M. Lleò,

Giovanni Malerba,

Carla Vignaroli

Publication year - 2021

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00302-21

Subject(s) - integron , plasmid , transposable element , biology , colistin , gene cassette , escherichia coli , multiple drug resistance , mcr 1 , tn10 , gene , virology , genetics , enterobacteriaceae , drug resistance , antibiotics , genome

We report a novel IncHI2 plasmid coharboring bla VIM-1 , two copies of bla KPC-3 , and mcr-9.1 resistance genes in a human Escherichia coli isolate of the new serogroup O188. The bla VIM-1 gene was included in a class 1 integron, mcr-9.1 in a cassette bracketed by IS 903 and ΔIS1R, and bla KPC-3 in two copies within a new composite Tn 4401 -like transposon. The emergence of carbapenem and colistin resistance genes in a single plasmid is of great concern for upcoming clinical therapies.

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