Bazedoxifene Suppresses Intracellular Mycobacterium tuberculosis Growth by Enhancing Autophagy | Zendy

Qi Ouyang | Zendy; Kehong Zhang | Zendy; Dachuan Lin | Zendy; Carl G. Feng | Zendy; Yi Cai | Zendy; Xinchun Chen | Zendy

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Bazedoxifene Suppresses Intracellular Mycobacterium tuberculosis Growth by Enhancing Autophagy

Author(s) -

Qi Ouyang,

Kehong Zhang,

Dachuan Lin,

Carl G. Feng,

Yi Cai,

Xinchun Chen

Publication year - 2020

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00124-20

Subject(s) - autophagy , tuberculosis , mycobacterium tuberculosis , drug , intracellular , immunity , medicine , drug resistance , biology , immunology , immune system , pharmacology , microbiology and biotechnology , genetics , apoptosis , pathology

Since current strategies for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) have low efficacy and highly negative side effects, research on new treatments including novel drugs is essential for curing drug-resistant tuberculosis. Host-directed therapy (HDT) has become a promising idea to modulate host cell responses to enhance protective immunity against pathogens. Bazedoxifene (BZA), which belongs to a new generation of SERMs, shows the ability to inhibit the growth of M. tuberculosis in macrophages and is associated with autophagy. Our findings reveal a previously unrecognized antibacterial function of BZA. We propose that the mechanism of SERMs action in macrophages may provide a new potential measure for host-directed therapies against TB.

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