Shigella -Specific Immune Profiles Induced after Parenteral Immunization or Oral Challenge with Either Shigella flexneri 2a or Shigella sonnei | Zendy

Kristen A. Clarkson | Zendy; Chad K. Porter | Zendy; Kawsar R. Talaat | Zendy; Robert W. Frenck | Zendy; Cristina Alaimo | Zendy; Patricia Martín | Zendy; A. Louis Bourgeois | Zendy; Robert W. Kaminski | Zendy

Open Access

Shigella -Specific Immune Profiles Induced after Parenteral Immunization or Oral Challenge with Either Shigella flexneri 2a or Shigella sonnei

Author(s) -

Kristen A. Clarkson,

Chad K. Porter,

Kawsar R. Talaat,

Robert W. Frenck,

Cristina Alaimo,

Patricia Martín,

A. Louis Bourgeois,

Robert W. Kaminski

Publication year - 2021

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00122-21

Subject(s) - shigellosis , shigella sonnei , shigella , shigella flexneri , immune system , immunology , immunization , microbiology and biotechnology , shigella boydii , medicine , biology , virology , salmonella , escherichia coli , bacteria , biochemistry , genetics , gene

Although immune correlates of protection have yet to be defined for shigellosis, prior studies have demonstrated thatShigella infection provides protection against reinfection in a serotype-specific manner. Therefore, it is likely that subjects with moderate to severe disease post-oral challenge would be protected from a homologous rechallenge, and investigating immune responses in these subjects may help identify immune markers associated with the development of protective immunity.

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