Open AccessShigella -Specific Immune Profiles Induced after Parenteral Immunization or Oral Challenge with Either Shigella flexneri 2a or Shigella sonnei
Author(s) -
Kristen A. Clarkson,
Chad K. Porter,
Kawsar R. Talaat,
Robert W. Frenck,
Cristina Alaimo,
Patricia A. Martín,
A. Louis Bourgeois,
Robert W. Kaminski
Publication year - 2021
Publication title -
msphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.749
H-Index - 39
ISSN - 2379-5042
DOI - 10.1128/msphere.00122-21
Subject(s) - shigellosis , shigella sonnei , shigella , shigella flexneri , immune system , immunology , immunization , microbiology and biotechnology , shigella boydii , medicine , biology , virology , salmonella , escherichia coli , bacteria , biochemistry , genetics , gene
Although immune correlates of protection have yet to be defined for shigellosis, prior studies have demonstrated thatShigella infection provides protection against reinfection in a serotype-specific manner. Therefore, it is likely that subjects with moderate to severe disease post-oral challenge would be protected from a homologous rechallenge, and investigating immune responses in these subjects may help identify immune markers associated with the development of protective immunity.