Open AccessCryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Author(s) -
Christopher Frøhlich,
João Alves Gama,
Klaus Harms,
Viivi H. A. Hirvonen,
Bjarte Aarmo Lund,
Marc W. van der Kamp,
Pål Jarle Johnsen,
Ørjan Samuelsen,
HannaKirsti S. Leiros
Publication year - 2021
Publication title -
msphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.749
H-Index - 39
ISSN - 2379-5042
DOI - 10.1128/msphere.00108-21
Subject(s) - ceftazidime , plasmid , antibiotic resistance , antibiotics , biology , microbiology and biotechnology , escherichia coli , antimicrobial , genetics , bacteria , gene , pseudomonas aeruginosa
Very low antibiotic concentrations have been shown to drive the evolution of antimicrobial resistance. While substantial progress has been made to understand the driving role of low concentrations during resistance development for different antimicrobial classes, the importance of β-lactams, the most commonly used antibiotics, is still poorly studied.