Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA | Zendy

Mia Jade Sales | Zendy; George Sakoulas | Zendy; Richard Szubin | Zendy; Bernhard Ø. Palsson | Zendy; César A. Arias | Zendy; Kavindra V. Singh | Zendy; Barbara E. Murray | Zendy; Jonathan M. Monk | Zendy

Open Access

Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA

Author(s) -

Mia Jade Sales,

George Sakoulas,

Richard Szubin,

Bernhard Ø. Palsson,

César A. Arias,

Kavindra V. Singh,

Barbara E. Murray,

Jonathan M. Monk

Publication year - 2020

Publication title -

microbiology resource announcements

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.383

H-Index - 35

ISSN - 2576-098X

DOI - 10.1128/mra.01515-19

Subject(s) - staphylococcus aureus , whole genome sequencing , microbiology and biotechnology , cefazolin , biology , peptide , antimicrobial , plasmid , strain (injury) , genome , bacteria , beta (programming language) , genetics , gene , antibiotics , biochemistry , anatomy , computer science , programming language

Staphylococcus aureus strain TX0117 is a methicillin-susceptible bacterium with type A beta-lactamase exhibiting a high cefazolin inoculum effect. TX0117 was cured of blaZ , yielding TX0117c with increased antimicrobial peptide resistance. The sequencing and genome assembly of TX0117 elucidate six mutations between TX0117 and TX0117c, including relA truncation and mnA_1 substitution.

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