Open AccessWidespread Traces of Lytic Kaposi Sarcoma-Associated Herpesvirus in Primary Effusion Lymphoma at Single-Cell Resolution
Author(s) -
Nicole C. Rondeau,
Michael O. Finlayson,
JJ L. Miranda
Publication year - 2020
Publication title -
microbiology resource announcements
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.383
H-Index - 35
ISSN - 2576-098X
DOI - 10.1128/mra.00851-20
Subject(s) - primary effusion lymphoma , lytic cycle , kaposi's sarcoma associated herpesvirus , virology , lymphoma , biology , virus , sarcoma , herpesviridae , medicine , viral disease , immunology , pathology
Cancer cells of primary effusion lymphoma (PEL) often contain both Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). We measured the interplay of human, KSHV, and EBV transcription in a cell culture model of PEL using single-cell RNA sequencing. The data detect widespread trace expression of lytic KSHV genes.