The Francisella tularensis Polysaccharides: What Is the Real Capsule? | Zendy

Kelly C. Freudenberger Catanzaro | Zendy; Thomas J. Inzana | Zendy

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The Francisella tularensis Polysaccharides: What Is the Real Capsule?

Author(s) -

Kelly C. Freudenberger Catanzaro,

Thomas J. Inzana

Publication year - 2020

Publication title -

microbiology and molecular biology reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.358

H-Index - 247

eISSN - 1098-5557

pISSN - 1092-2172

DOI - 10.1128/mmbr.00065-19

Subject(s) - francisella tularensis , tularemia , biology , virulence , francisella , microbiology and biotechnology , bacterial capsule , capsule , immune system , bacteria , virology , immunology , genetics , gene , botany

Francisella tularensis is a tier 1 select agent responsible for tularemia in humans and a wide variety of animal species. Extensive research into understanding the virulence factors of the bacterium has been ongoing to develop an efficacious vaccine. At least two such virulence factors are described as capsules ofF. tularensis : the O-antigen capsule and the capsule-like complex (CLC). These two separate entities aid in avoiding host immune defenses but have not been clearly differentiated.

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