Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer | Zendy

Matteo Bellone | Zendy; Arianna Brevi | Zendy; Samuel Huber | Zendy

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Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer

Author(s) -

Matteo Bellone,

Arianna Brevi,

Samuel Huber

Publication year - 2020

Publication title -

microbiology and molecular biology reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.358

H-Index - 247

eISSN - 1098-5557

pISSN - 1092-2172

DOI - 10.1128/mmbr.00064-19

Subject(s) - biology , immune system , microbiome , immunology , cancer , ovarian cancer , psoriasis , multiple myeloma , multiple sclerosis , bioinformatics , genetics

Technologies allowing genetic sequencing of the human microbiome are opening new realms to discovery. The host microbiota substantially impacts immune responses both in immune-mediated inflammatory diseases (IMIDs) and in tumors affecting tissues beyond skin and mucosae. However, a mechanistic link between host microbiota and cancer or IMIDs has not been well established. Here, we propose T helper 17 (TH 17) lymphocytes as the connecting factor between host microbiota and rheumatoid or psoriatic arthritides, multiple sclerosis, breast or ovarian cancer, and multiple myeloma.

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