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A Thermosensitive, Phase-Variable Epigenetic Switch: pap Revisited
Author(s) -
Mario Zamora,
Christine A. Ziegler,
Peter L. Freddolino,
Alan J. Wolfe
Publication year - 2020
Publication title -
microbiology and molecular biology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.358
H-Index - 247
eISSN - 1098-5557
pISSN - 1092-2172
DOI - 10.1128/mmbr.00030-17
Subject(s) - biology , epigenetics , genetics , computational biology , mutant , virulence , phase variation , gene
It has been more than a decade since the last comprehensive review of the phase-variable uropathogen-associated pyelonephritis-associated pilus ( pap ) genetic switch. Since then, important data have come to light, including additional factors that regulate pap expression, better characterization of H-NS regulation, the structure of the Lrp octamer in complex with pap regulatory DNA, the temperature-insensitive phenotype of a mutant lacking the acetyltransferase RimJ, evidence that key components of the regulatory machinery are acetylated, and new insights into the role of DNA binding by key regulators in shaping both the physical structure and regulatory state of the papI and papBA promoters. This review revisits pap , integrating these newer observations with older ones to produce a new model for the concerted behavior of this virulence-regulatory region.

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