Open AccessTissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice.
Author(s) -
J Allison,
Y L Zhang,
M G Parker
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.5.2254
Subject(s) - biology , gene , transgene , testosterone (patch) , gene expression , microbiology and biotechnology , regulatory sequence , hormone , genetically modified mouse , regulation of gene expression , prostate , steroid hormone , endocrinology , genetics , cancer
We investigated the tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein by introducing the C3(1) gene with 4-kilobase (kb) upstream and 2-kb downstream flanking sequences into transgenic mice. There was selective expression in the ventral prostate that was stimulated by testosterone, which indicated that the gene together with 6-kb flanking DNA contains the information required for prostate-specific and testosterone-regulated expression.