Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice. | Zendy

J Allison | Zendy; Y L Zhang | Zendy; M G Parker | Zendy

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Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice.

Author(s) -

J Allison,

Y L Zhang,

M G Parker

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.5.2254

Subject(s) - biology , gene , transgene , testosterone (patch) , gene expression , microbiology and biotechnology , regulatory sequence , hormone , genetically modified mouse , regulation of gene expression , prostate , steroid hormone , endocrinology , genetics , cancer

We investigated the tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein by introducing the C3(1) gene with 4-kilobase (kb) upstream and 2-kb downstream flanking sequences into transgenic mice. There was selective expression in the ventral prostate that was stimulated by testosterone, which indicated that the gene together with 6-kb flanking DNA contains the information required for prostate-specific and testosterone-regulated expression.

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