Open AccessA novel pathway for transversion mutation induced by dCTP misincorporation in a mutator strain of CHO cells.
Author(s) -
Geraldine Phear,
M Meuth
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.4.1810
Subject(s) - transversion , biology , dna replication , microbiology and biotechnology , dna , genetics , locus (genetics) , mutation , gene
Intracellular imbalances of dCTP produce both T----C transitions and an unusual class of transversions (A----C) at the aprt locus of CHO cells. Our data suggest that this transversion pathway is the consequence of dCTP:T mispairs which are not efficiently proofread during DNA replication.
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