Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes. | Zendy

Michael E. Lambert | Zendy; Ze’ev A. Ronai | Zendy; I. Bernard Weinstein | Zendy; James I. Garrels | Zendy

Open Access

Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.

Author(s) -

Michael E. Lambert,

Ze’ev A. Ronai,

I. Bernard Weinstein,

James I. Garrels

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.2.847

Subject(s) - biology , cycloheximide , major histocompatibility complex , dna damage , microbiology and biotechnology , dna , keratinocyte , mhc class i , histocompatibility , dna synthesis , human skin , protein biosynthesis , cell culture , virology , genetics , antigen , human leukocyte antigen

Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research