Open AccessMetal-specific posttranscriptional control of human metallothionein genes.
Author(s) -
C Sadhu,
Lashitew Gedamu
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.12.5738
Subject(s) - metallothionein , biology , zinc , transcription (linguistics) , messenger rna , microbiology and biotechnology , gene expression , hepatoblastoma , gene , regulation of gene expression , biochemistry , medicine , chemistry , linguistics , philosophy , organic chemistry
During the initial 4 h of treatment, copper and zinc similarly activated the rates of transcription and mRNA accumulation from the two human metallothionein (MT) genes, viz., MTI-G and MTII-A, in the hepatoblastoma cell line HepG2. The levels of copper-induced MT mRNAs remained at a plateau for up to 15 h. In contrast, the levels of zinc-induced MT mRNAs gradually declined after about 4 h, despite substantial transcription. The decrease in the zinc-induced MT mRNA half-life is probably due to a posttranscriptional event(s).