Metal-specific posttranscriptional control of human metallothionein genes. | Zendy

C Sadhu | Zendy; Lashitew Gedamu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metal-specific posttranscriptional control of human metallothionein genes.

Author(s) -

C Sadhu,

Lashitew Gedamu

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.12.5738

Subject(s) - metallothionein , biology , zinc , transcription (linguistics) , messenger rna , microbiology and biotechnology , gene expression , hepatoblastoma , gene , regulation of gene expression , biochemistry , medicine , chemistry , linguistics , philosophy , organic chemistry

During the initial 4 h of treatment, copper and zinc similarly activated the rates of transcription and mRNA accumulation from the two human metallothionein (MT) genes, viz., MTI-G and MTII-A, in the hepatoblastoma cell line HepG2. The levels of copper-induced MT mRNAs remained at a plateau for up to 15 h. In contrast, the levels of zinc-induced MT mRNAs gradually declined after about 4 h, despite substantial transcription. The decrease in the zinc-induced MT mRNA half-life is probably due to a posttranscriptional event(s).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research