Open AccessDevelopmental expression of transforming growth factors alpha and beta in mouse fetus.
Author(s) -
Josiah N. Wilcox,
Rik Derynck
Publication year - 1988
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.8.8.3415
Subject(s) - biology , fetus , in situ hybridization , alpha (finance) , messenger rna , placenta , transforming growth factor beta , haematopoiesis , gene expression , endocrinology , tgf alpha , medicine , transforming growth factor , microbiology and biotechnology , cell culture , gene , pregnancy , stem cell , epidermal growth factor , biochemistry , construct validity , genetics , nursing , patient satisfaction
Expression of mRNA for transforming growth factor alpha (TGF-alpha) and TGF-beta 1 during the fetal development of mice was evaluated by in situ hybridization. TGF-alpha mRNA was detected in 9- and 10-day fetuses but was absent in older fetuses. TGF-alpha mRNA-containing cells were found in the placenta, otic vesicle, oral cavity, pharyngeal pouch, first and second branchial arches, and developing kidneys. mRNA for TGF-beta 1 was present in hematopoietic cells of blood islands and capillaries and in the liver as it began to bud off on day 10 and function as a hematopoietic organ.