Developmental expression of transforming growth factors alpha and beta in mouse fetus. | Zendy

J N Wilcox | Zendy; Rik Derynck | Zendy

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Developmental expression of transforming growth factors alpha and beta in mouse fetus.

Author(s) -

J N Wilcox,

Rik Derynck

Publication year - 1988

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.8.8.3415

Subject(s) - biology , fetus , in situ hybridization , alpha (finance) , messenger rna , placenta , transforming growth factor beta , haematopoiesis , gene expression , endocrinology , tgf alpha , medicine , transforming growth factor , microbiology and biotechnology , cell culture , gene , pregnancy , stem cell , epidermal growth factor , biochemistry , construct validity , genetics , nursing , patient satisfaction

Expression of mRNA for transforming growth factor alpha (TGF-alpha) and TGF-beta 1 during the fetal development of mice was evaluated by in situ hybridization. TGF-alpha mRNA was detected in 9- and 10-day fetuses but was absent in older fetuses. TGF-alpha mRNA-containing cells were found in the placenta, otic vesicle, oral cavity, pharyngeal pouch, first and second branchial arches, and developing kidneys. mRNA for TGF-beta 1 was present in hematopoietic cells of blood islands and capillaries and in the liver as it began to bud off on day 10 and function as a hematopoietic organ.

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