p53 increases experimental metastatic capacity of murine carcinoma cells. | Zendy

J Pohl | Zendy; Naomi Goldfinger | Zendy; Adriana RadlerPohl | Zendy; Varda Rotter | Zendy; Volker Schirrmacher | Zendy

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p53 increases experimental metastatic capacity of murine carcinoma cells.

Author(s) -

J Pohl,

Naomi Goldfinger,

Adriana RadlerPohl,

Varda Rotter,

Volker Schirrmacher

Publication year - 1988

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.8.5.2078

Subject(s) - biology , transfection , cancer research , cell culture , in vitro , carcinoma , gene , cell growth , microbiology and biotechnology , cell , genetics

Transfection of a cloned p53 gene into a murine bladder carcinoma cell with a low metastatic capacity led to elevated levels of p53 protein in clonal transfectants. After intravenous inoculation into syngeneic mice, p53-transfected clones showed significantly increased metastatic potential in comparison with control transfectants. The observed change did not seem to be due to a change in growth potential per se since the cell lines showed similar growth properties in vitro.

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