Open Accessp53 increases experimental metastatic capacity of murine carcinoma cells.
Author(s) -
Juergen Pohl,
Naomi Goldfinger,
Adriana RadlerPohl,
Varda Rotter,
Volker Schirrmacher
Publication year - 1988
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.8.5.2078
Subject(s) - biology , transfection , cancer research , cell culture , in vitro , carcinoma , gene , cell growth , microbiology and biotechnology , cell , genetics
Transfection of a cloned p53 gene into a murine bladder carcinoma cell with a low metastatic capacity led to elevated levels of p53 protein in clonal transfectants. After intravenous inoculation into syngeneic mice, p53-transfected clones showed significantly increased metastatic potential in comparison with control transfectants. The observed change did not seem to be due to a change in growth potential per se since the cell lines showed similar growth properties in vitro.