Open AccessCarcinogen-induced trans activation of gene expression.
Author(s) -
Tamar Kleinberger,
Y B Flint,
Marissa C. Blank,
Sara Etkin,
Sara Lavi
Publication year - 1988
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.8.3.1366
Subject(s) - biology , carcinogen , gene expression , gene , regulation of gene expression , genetics , mechanism (biology) , microbiology and biotechnology , mechanism of action , in vitro , philosophy , epistemology
We report a new mechanism of carcinogen action by which the expression of several genes was concomitantly enhanced. This mechanism involved the altered activity of cellular factors which modulate the expression of genes under their control. The increased expression was regulated at least in part on the transcriptional level and did not require amplification of the overexpressed genes. This phenomenon was transient; it was apparent as early as 24 h after carcinogen treatment and declined a few days later.