Open AccessDevelopmental expression of two forms of pp60c-src in mouse brain.
Author(s) -
Otmar D. Wiestler,
Gernot Walter
Publication year - 1988
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.8.1.502
Subject(s) - biology , forebrain , microbiology and biotechnology , tyrosine kinase , embryo , proto oncogene tyrosine protein kinase src , embryonic stem cell , midbrain , embryogenesis , gene , kinase , endocrinology , biochemistry , signal transduction , central nervous system
The expression during mouse development of two forms of protein-tyrosine kinase pp60c-src, pp60 and pp60+, was investigated. At embryonic day 9 (E9), only pp60 was detected in whole-brain lysates. A trace of pp60+ was first seen at E10. In E18 embryos and in adults, pp60+ was the predominant form of pp60c-src in forebrain and midbrain lysates.