Human hTM alpha gene: expression in muscle and nonmuscle tissue. | Zendy

Alexander R. MacLeod | Zendy; Clare Gooding | Zendy

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Human hTM alpha gene: expression in muscle and nonmuscle tissue.

Author(s) -

Alexander R. MacLeod,

Clare Gooding

Publication year - 1988

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.8.1.433

Subject(s) - biology , tropomyosin , skeletal muscle , gene isoform , microbiology and biotechnology , alternative splicing , gene , complementary dna , cdna library , gene expression , alpha (finance) , genetics , actin , anatomy , medicine , construct validity , nursing , patient satisfaction

We have isolated a cDNA clone from a human skeletal muscle library which contains the complete protein-coding sequence of a skeletal muscle alpha-tropomyosin. This cDNA sequence defines a fourth human tropomyosin gene, the hTM alpha gene, which is distinct from the hTMnm gene encoding a closely related isoform of skeletal muscle alpha-tropomyosin. In cultured human fibroblasts, the hTM alpha gene encodes both skeletal-muscle- and smooth-muscle-type alpha-tropomyosins by using an alternative mRNA-splicing mechanism.

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