Extinction of expression of immunoglobulin genes in myeloma X fibroblast somatic cell hybrids. | Zendy

Aviva Greenberg | Zendy; Raphael Ber | Zendy; Z Kra-Oz | Zendy; Reuven Laskov | Zendy

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Extinction of expression of immunoglobulin genes in myeloma X fibroblast somatic cell hybrids.

Author(s) -

Aviva Greenberg,

Raphael Ber,

Z Kra-Oz,

Reuven Laskov

Publication year - 1987

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.7.2.936

Subject(s) - biology , immunoglobulin heavy chain , antibody , immunoglobulin light chain , immunoglobulin gene , microbiology and biotechnology , gene , myeloma protein , genetics

Adherent hybrids between immunoglobulin-producing mouse myeloma cells and fibroblasts do not produce immunoglobulin polypeptide chains. These hybrids retained the actively rearranged immunoglobulin genes of the myeloma parental cells but lacked immunoglobulin heavy- and light-chain RNA transcripts. We conclude that the shutoff of immunoglobulin production in these hybrids occurs at the transcription or early processing level.

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