Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene. | Zendy

Dennis J. Thiele | Zendy; Dean H. Hamer | Zendy

Open Access

Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene.

Author(s) -

Dennis J. Thiele,

Dean H. Hamer

Publication year - 1986

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.6.4.1158

Subject(s) - biology , saccharomyces cerevisiae , metallothionein , transcription (linguistics) , heterologous , genetics , gene , promoter , mutant , microbiology and biotechnology , gene expression , linguistics , philosophy

Transcription of the Saccharomyces cerevisiae copper-metallothionein gene, CUP1, inducible by copper. By analyzing deletion and fusion mutants in the CUP1 5'-flanking region, we identified two closely related, tandemly arranged copper regulatory elements. A synthetic version of one of these elements conferred efficient copper induction on a heterologous promoter when present in two tandem copies.

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