Open AccessNonexpression of a major heat shock gene in mouse plasmacytoma MPC-11.
Author(s) -
Luc Aujame,
Clinton T. Morgan
Publication year - 1985
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.5.7.1780
Subject(s) - biology , plasmacytoma , gene , microbiology and biotechnology , rna , heat shock protein , transcription (linguistics) , heat shock , genetics , multiple myeloma , immunology , linguistics , philosophy
The major heat shock gene coding for a 68,000-dalton protein was found to be silent in mouse plasmacytoma MPC-11 in both control and stressed cells. The block appears to be at the level of transcription, although RNA processing or instability has not been ruled out. It is not caused by a major deletion or rearrangement of the gene.