Family of human alpha-interferon-like sequences. | Zendy

Sheldon I. Feinstein | Zendy; Y Mory | Zendy; Yuti Chernajovsky | Zendy; Luc Maroteaux | Zendy; Uri Nir | Zendy; Vered Lavie | Zendy; Michel Revel | Zendy

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Family of human alpha-interferon-like sequences.

Author(s) -

Sheldon I. Feinstein,

Y Mory,

Yuti Chernajovsky,

Luc Maroteaux,

Uri Nir,

Vered Lavie,

Michel Revel

Publication year - 1985

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.5.3.510

Subject(s) - biology , alpha interferon , gene , genetics , homology (biology) , microbiology and biotechnology , interferon , oligonucleotide , genomic library , nucleic acid sequence , peptide sequence

An interferon-alpha-like sequence was isolated from a human genomic library by hybridization with a 15-base oligonucleotide. The sequence also showed homology to alpha-interferon and was most closely related to the leukocyte interferon-M gene fragment. The original isolate cross-hybridized to a family of sequences, 10 of which were isolated as clones. Some of these sequences were located within a few kilobases of alpha-interferon genes, consistent with our assignment of several members of the family to human chromosome 9 which also has the beta 1- and alpha-interferon genes.

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