Open AccessFamily of human alpha-interferon-like sequences.
Author(s) -
Sheldon I. Feinstein,
Y. Mory,
Yuti Chernajovsky,
Luc Maroteaux,
Uri Nir,
Vered Lavie,
Michel Revel
Publication year - 1985
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.5.3.510
Subject(s) - biology , alpha interferon , gene , genetics , homology (biology) , microbiology and biotechnology , interferon , oligonucleotide , genomic library , nucleic acid sequence , peptide sequence
An interferon-alpha-like sequence was isolated from a human genomic library by hybridization with a 15-base oligonucleotide. The sequence also showed homology to alpha-interferon and was most closely related to the leukocyte interferon-M gene fragment. The original isolate cross-hybridized to a family of sequences, 10 of which were isolated as clones. Some of these sequences were located within a few kilobases of alpha-interferon genes, consistent with our assignment of several members of the family to human chromosome 9 which also has the beta 1- and alpha-interferon genes.