Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells. | Zendy

Masatoshi Shibuya | Zendy; Jun Yokota | Zendy; Yoshito Ueyama | Zendy

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Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells.

Author(s) -

Masatoshi Shibuya,

Jun Yokota,

Yoshito Ueyama

Publication year - 1985

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.5.2.414

Subject(s) - biology , oncogene , karyotype , microbiology and biotechnology , adenocarcinoma , cancer research , dna , rna , gene , cancer , chromosome , genetics , cell cycle

Three of 16 human gastric adenocarcinoma samples, maintained as solid tumors in nude mice, were found to carry amplified c-myc genes. In two samples with a high degree of c-myc DNA amplification (15- to 30-fold), double minute chromosomes were observed in karyotype analysis. The level of c-myc RNA was markedly elevated in a rapidly growing and poorly differentiated tumor, whereas it was only slightly elevated in a slowly growing and more differentiated tumor.

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