Expression of simian virus 40 large T antigen in embryonal carcinoma cell hybrids. | Zendy

Alan Tunnacliffe | Zendy; L. V. Crawford | Zendy; Peter N. Goodfellow | Zendy

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Expression of simian virus 40 large T antigen in embryonal carcinoma cell hybrids.

Author(s) -

Alan Tunnacliffe,

L. V. Crawford,

Peter N. Goodfellow

Publication year - 1984

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.4.8.1657

Subject(s) - biology , embryonal carcinoma , virus , virology , simian , antigen , teratocarcinoma , cellular differentiation , immunology , genetics , gene

Previous work has shown that murine embryonal carcinoma cells are refractory to infection with various viruses, including simian virus 40. Thus, large T and small t antigens, the products of the simian virus 40 early region, are not produced when the virus infects embryonal carcinoma cells, in contrast to other cell types. We show, by qualitative and quantitative analyses, that embryonal carcinoma cell hybrids, containing a simian virus 40 early region integrated into human DNA, are capable of producing viral large T antigen.

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