Open AccessPolyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo.
Author(s) -
Claude Asselin,
Céline Gélinas,
Philip E. Branton,
Marcel Bastin
Publication year - 1984
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.4.4.755
Subject(s) - biology , antigen , phenotype , recombinant dna , gene , virology , in vivo , microbiology and biotechnology , sv40 large t antigen , polyoma virus , virus , transfection , genetics
The oncogenic potential of polyomavirus in newborn hamsters can be expressed by a recombinant encoding only the middle T protein. However, polyoma middle T requires the cooperation from small T to induce tumors in newborn rats. Similar complementary functions such as cocarcinogens or tumor promotors can be exerted by the simian virus 40 T antigens as well as by one or several products of the early region 1A of adenovirus 2.