Open AccessChromosomal assignment of the murine gene encoding the transformation-related protein p53.
Author(s) -
Varda Rotter,
D. Wolf,
Dimitrina D. Pravtcheva,
Frank H. Ruddle
Publication year - 1984
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.4.2.383
Subject(s) - biology , chinese hamster , gene , transformation (genetics) , microbiology and biotechnology , genetics , chromosome , genome , hamster , cell culture
p53 is a transformation-related protein that is encoded by the cellular genome and is synthesized at elevated levels in a wide range of different cell line types and in primary tumors of various species. By using several independently established anti-p53 monoclonal antibodies, it was possible to distinguish between p53 of mouse origin and p53 of Chinese hamster origin. By analysis of a series of mouse X Chinese hamster hybrid cell lines containing various mouse chromosomes, we mapped the p53 gene product to mouse chromosome 11.