Open AccessAdenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.
Author(s) -
B F Cheetham,
D C Shaw,
A. J. D. Bellett
Publication year - 1982
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.2.10.1295
Subject(s) - biology , thymidine kinase , polyamine , thymidine , ornithine decarboxylase , dna synthesis , microbiology and biotechnology , adenoviridae , dna replication , kinase , biochemistry , dna , enzyme , virology , virus , gene , herpes simplex virus , recombinant dna
Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.