Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation. | Zendy

B F Cheetham | Zendy; D. C. Shaw | Zendy; A. J. D. Bellett | Zendy

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Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.

Author(s) -

B F Cheetham,

D. C. Shaw,

A. J. D. Bellett

Publication year - 1982

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.2.10.1295

Subject(s) - biology , thymidine kinase , polyamine , thymidine , ornithine decarboxylase , dna synthesis , microbiology and biotechnology , adenoviridae , dna replication , kinase , biochemistry , dna , enzyme , virology , virus , gene , herpes simplex virus , recombinant dna

Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.

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