Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src. | Zendy

Tung O. Chan | Zendy; Akio Tanaka | Zendy; Jeffrey D. Bjorge | Zendy; Daishi Fujita | Zendy

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Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.

Author(s) -

Tung O. Chan,

Akio Tanaka,

Jeffrey D. Bjorge,

Daishi Fujita

Publication year - 1990

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.10.6.3280

Subject(s) - biology , tyrosine kinase , phosphatidylinositol , proto oncogene tyrosine protein kinase src , kinase , microbiology and biotechnology , signal transduction , biochemistry

Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.

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