Open AccessThe amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.
Author(s) -
Gregory D. Plowman,
J M Green,
V L McDonald,
M G Neubauer,
C M Disteche,
George J. Todaro,
M. Shoyab
Publication year - 1990
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.10.5.1969
Subject(s) - amphiregulin , biology , tgf alpha , epidermal growth factor , transforming growth factor , epidermal growth factor receptor , microbiology and biotechnology , growth factor , cell growth , transmembrane protein , transforming growth factor, beta 3 , cancer research , cell culture , receptor , genetics
We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is a bifunctional growth modulator: it interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. The 84-amino-acid mature protein is embedded within a 252-amino-acid transmembrane precursor, an organization similar to that of the TGF-alpha precursor. Human placenta and ovaries were found to express significant amounts of the 1.4-kilobase AR transcript, implicating AR in the regulation of normal cell growth. In addition, the AR gene was localized to chromosomal region 4q13-4q21, a common breakpoint for acute lymphoblastic leukemia.
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