Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt | Zendy

Kang Liu | Zendy; Joshua D. Graves | Zendy; YuJu Lee | Zendy; FangTsyr Lin | Zendy; Weei-Chin Lin | Zendy

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Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt

Author(s) -

Kang Liu,

Joshua D. Graves,

YuJu Lee,

FangTsyr Lin,

Weei-Chin Lin

Publication year - 2020

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00599-19

Subject(s) - biology , origin recognition complex , dna replication , eukaryotic dna replication , pre replication complex , dna replication factor cdt1 , control of chromosome duplication , microbiology and biotechnology , cyclin a , cyclin dependent kinase 2 , s phase , cell cycle , replication factor c , dna , cyclin dependent kinase , genetics , phosphorylation , protein kinase a , cancer

Cdk2-dependent TopBP1-treslin interaction is critical for DNA replication initiation. However, it remains unclear how this association is terminated after replication initiation is finished. Here, we demonstrate that phosphorylation of TopBP1 by Akt coincides with cyclin A activation during S and G2 phases and switches the TopBP1-interacting partner from treslin to E2F1, which results in the termination of replication initiation. Premature activation of Akt in G1 phase causes an early switch and inhibits DNA replication.

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