E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis | Zendy

Hui Chen | Zendy; Mudunov Ali | Zendy; Azizyan Ruben | Zendy; Dimitry Stelmakh | Zendy; Maksim Pak | Zendy

Open Access

E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis

Author(s) -

Hui Chen,

Mudunov Ali,

Azizyan Ruben,

Dimitry Stelmakh,

Maksim Pak

Publication year - 2020

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00496-19

Subject(s) - downregulation and upregulation , biology , carcinogenesis , microbiology and biotechnology , cell growth , cancer research , transcription factor , gene expression , regulation of gene expression , gene , genetics

Recently, abundant evidence has clarified that long noncoding RNAs (lncRNAs) play an oncogenic or anticancer role in the tumorigenesis and development of diverse human cancers. Described as a crucial regulator in some cancers, MIR22HG has not yet been studied in laryngocarcinoma and therefore the underlying regulatory role of MIR22HG in laryngocarcinoma is worth detecting. In this study, MIR22HG expression in laryngocarcinoma cells was confirmed to be downregulated, and upregulated MIR22HG expression led to suppressive effects on laryngocarcinoma cell proliferation and migration.

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