Open AccessThe S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA
Author(s) -
Mitsuhiro Goto,
Mariko Sasaki,
Takehiko Kobayashi
Publication year - 2021
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00324-20
Subject(s) - biology , dna replication , genetics , control of chromosome duplication , origin recognition complex , genome instability , pre replication complex , s phase , homologous recombination , eukaryotic dna replication , microbiology and biotechnology , dna , dna damage
Regulation of replication origins is important for complete duplication of the genome, but the effect of origin activation on the cellular response to replication stress is poorly understood. The budding yeast rRNA gene (rDNA) forms tandem repeats and undergoes replication fork arrest at the replication fork barrier (RFB), inducing DNA double-strand breaks (DSBs) and genome instability accompanied by copy number alterations.