Open AccessAugmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence
Author(s) -
Ruchi Jain Dey,
Bappaditya Dey,
Melanie J. Harriff,
Elizabeth T. Canfield,
David Lewinsohn,
William R. Bishai
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03865-21
Subject(s) - mycobacterium tuberculosis , tuberculosis , virulence , microbiology and biotechnology , biology , immune system , immunology , t cell , gene , medicine , biochemistry , pathology
Mucosa-associated invariant T (MAIT) cells are an important subset of innate lymphocytes that recognize microbial ligands derived from the riboflavin biosynthesis pathway and mediate antimicrobial immune responses. Modulated MAIT cell responses have been noted in different forms of tuberculosis.