Open AccessSulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor
Author(s) -
Ting Lu,
Xiaohua Wu,
Qun Cao,
Yongzhen Xia,
Luying Xun,
Huaiwei Liu
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03862-21
Subject(s) - actinorhodin , streptomyces coelicolor , gene , biology , transcription factor , streptomyces , promoter , regulator , transcriptional regulation , regulation of gene expression , transcription (linguistics) , microbiology and biotechnology , biochemistry , gene expression , genetics , bacteria , mutant , linguistics , philosophy
Streptomyces species produce a myriad of natural products with (potential) clinical applications. While the database of biosynthetic gene clusters is quickly expanding, their regulation mechanisms are rarely known.