Open AccessLow-Dose Exposure to Ganglioside-Mimicking Bacteria Tolerizes Human Macrophages to Guillain-Barré Syndrome-Associated Antigens
Author(s) -
Robert T. Patry,
Lauren Essler,
Silke Andresen,
Frederick D. Quinn,
Christine M. Szymanski
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03852-21
Subject(s) - campylobacter jejuni , molecular mimicry , immunology , immune system , antigen , biology , guillain barre syndrome , microbiology and biotechnology , proinflammatory cytokine , bacteria , inflammation , genetics
In this study, we demonstrated that it is possible to tolerize immune cells to potentially dampen the autoreactive proinflammatory immune response against Guillain-Barré syndrome (GBS)-associated antigens. The innate immune response functions to arm the host against bacterial attack, but it can be tricked into recognizing the host’s own cells when infectious bacteria display sugar structures that mimic human glycans.