Open AccessMolecular Basis of Rhodomyrtone Resistance in Staphylococcus aureus
Author(s) -
Li Huang,
Miki Matsuo,
Carlos Calderón,
Sook-Ha Fan,
Aparna Viswanathan Ammanath,
Xiaoqing Fu,
Ningna Li,
Arif Luqman,
M. Ullrich,
Florian Herrmann,
Martin E. Maier,
Anchun Cheng,
Fajun Zhang,
Filipp Oesterhelt,
Michael Lämmerhofer,
Friedrich Götz
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03833-21
Subject(s) - isothermal titration calorimetry , staphylococcus aureus , chemistry , mutant , efflux , lipidome , gene , regulator , biochemistry , downregulation and upregulation , strain (injury) , microbiology and biotechnology , bacteria , biology , genetics , lipidomics , anatomy
Antibiotic resistance is a growing public health problem, and alternative antibiotics are urgently needed. Rhodomyrtone (Rom), an antimicrobial compound originally isolated fromRhodomyrtus tomentosa , is active against multiple resistant Gram-positive pathogens.