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Molecular Basis of Rhodomyrtone Resistance in Staphylococcus aureus
Author(s) -
Li Huang,
Miki Matsuo,
Carlos Calderón,
SookHa Fan,
Aparna Viswanathan Ammanath,
Xiaoqing Fu,
Ningna Li,
Arif Luqman,
M. Ullrich,
Florian Herrmann,
Martin E. Maier,
Anchun Cheng,
Fajun Zhang,
Filipp Oesterhelt,
Michael Lämmerhofer,
Friedrich Götz
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03833-21
Subject(s) - isothermal titration calorimetry , staphylococcus aureus , chemistry , efflux , mutant , gene , lipidome , regulator , biochemistry , microbiology and biotechnology , point mutation , strain (injury) , bacteria , biology , genetics , lipidomics , anatomy
Antibiotic resistance is a growing public health problem, and alternative antibiotics are urgently needed. Rhodomyrtone (Rom), an antimicrobial compound originally isolated fromRhodomyrtus tomentosa , is active against multiple resistant Gram-positive pathogens.

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