Open AccessSculpting the Bacterial O -Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities
Author(s) -
Chris Hadjineophytou,
Jan Haug Asen,
Tina Svingerud,
Tatum D Mortimer,
Yonatan H. Grad,
Nichollas E. Scott,
Michael Koomey
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03797-21
Subject(s) - pilin , glycosylation , biology , glycan , pilus , glycoprotein , neisseria , microbiology and biotechnology , neisseria gonorrhoeae , clade , convergent evolution , bacteria , genetics , phylogenetics , computational biology , gene , virulence
Although general protein glycosylation systems have been well recognized in prokaryotes, the processes governing their distribution, function, and evolution remain poorly understood. Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrumO -linked protein glycosylation manifest in species within the genusNeisseria that strictly colonize humans.