Open AccessRegnase-1 Deficiency Restrains Klebsiella pneumoniae Infection by Regulation of a Type I Interferon Response
Author(s) -
Giraldina Trevejo-Nuñez,
Becky Lin,
Li Fan,
Felix E.Y. Aggor,
Partha S. Biswas,
Kong Chen,
Sarah L. Gaffen
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03792-21
Subject(s) - immunology , inflammation , immune system , immunity , autoimmunity , biology , regulator , medicine , gene , biochemistry
Klebsiella pneumoniae (KP) can cause life-threatening bacterial pneumonia and is the third most common cause of ventilator-associated pneumonia in the United States. Host inflammatory responses to infection are necessary to control disease, yet at the same time can cause collateral damage or immunopathology.