Open AccessIdentification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model
Author(s) -
Sebastian Suerbaum,
Nina Coombs,
Lubna Patel,
Dimitri Pscheniza,
Katharina Rox,
Christine S. Falk,
Achim D. Gruber,
Olivia Kershaw,
Patrick Chhatwal,
Mark Brönstrup,
Ursula Bilitewski,
Christine Josenhans
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03755-21
Subject(s) - flagellin , helicobacter pylori , microbiology and biotechnology , motility , virulence , pathogen , flagellum , antibiotics , secretion , antibiotic resistance , biology , virulence factor , bacteria , gene , biochemistry , genetics
Helicobacter pylori is one of the most prevalent bacterial pathogens, inflicting hundreds of thousands of peptic ulcers and gastric cancers to patients every year. Antibacterial treatment ofH. pylori is complicated due to the need of combining multiple antibiotics, entailing serious side effects and increasing selection for antibiotic resistance.