Open AccessEngineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41
Author(s) -
Alexandra Maslennikova,
Natalia Kruglova,
С. В. Калиниченко,
Dmitriy Komkov,
М. В. Шепелев,
D. B. Golubev,
Andrei E. Siniavin,
Andrei N. Vzorov,
Alexander Filatov,
Dmitriy Mazurov
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03589-21
Subject(s) - heptad repeat , gp41 , peptide , microbiology and biotechnology , epitope , biology , virology , chemistry , peptide sequence , antibody , biochemistry , genetics , gene
HIV is a human lentivirus that infects CD4-positive immune cells and, when left untreated, manifests in the fatal disease known as AIDS. Antiretroviral therapy (ART) does not leading to viral clearance, and HIV persists in the organism as a latent provirus.