Open AccessCryo-Electron Tomography of the Herpesvirus Procapsid Reveals Interactions of the Portal with the Scaffold and a Shift on Maturation
Author(s) -
Michael H. C. Buch,
William W. Newcomb,
Dennis C. Winkler,
Alasdair C. Steven,
J. Bernard Heymann
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03575-20
Subject(s) - herpes simplex virus , virus , virology , scaffold protein , biology , encephalitis , neuroscience , disease , microbiology and biotechnology , medicine , pathology , signal transduction
Herpes simplex virus 1 (HSV-1) infects a majority of humans, causing mostly mild disease but in some cases progressing toward life-threatening encephalitis. Understanding the life cycle of the virus is important to devise countermeasures.