Open AccessIn Vivo Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression
Author(s) -
Yong Jun Goh,
Rodolphe Barrangou,
Todd R. Klaenhammer
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03399-20
Subject(s) - lactobacillus acidophilus , probiotic , biology , colonization , transcriptome , in vivo , gene , host (biology) , gene expression , microbiology and biotechnology , bacteria , genetics
To date, our basis for comprehending the probiotic mechanisms of Lactobacillus acidophilus , one of the most widely consumed probiotic microbes, was largely limited to in vitro functional genomic studies. Using a germfree murine colonization model, in vivo -based transcriptional studies provided the first view of how L. acidophilus survives in the mammalian gut environment, including gene expression patterns linked to survival, efficient nutrient acquisition, stress adaptation, and host interactions.