Open AccessIS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics
Author(s) -
Dawei Wei,
Nai-Kei Wong,
Yuqin Song,
Gang Zhang,
Chao Wang,
Juan Li,
Jie Feng
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03340-21
Subject(s) - antibiotics , carbapenem , biology , microbiology and biotechnology , medicine
Klebsiella pneumoniae carbapenemases (KPCs) are powerfulβ -lactamases that enable Gram-negative pathogens to destroy clinically important carbapenems in antibiotic therapies. In particular, KPC-2 is difficult to detect due to a lack of instrument sensitivity in regular laboratory screens, which leads to misdiagnosis and poor treatment outcomes.