IS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics | Zendy

Dawei Wei | Zendy; Nai-Kei Wong | Zendy; Yuqin Song | Zendy; Gang Zhang | Zendy; Chao Wang | Zendy; Juan Li | Zendy; Jie Feng | Zendy

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IS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

Author(s) -

Dawei Wei,

Nai-Kei Wong,

Yuqin Song,

Gang Zhang,

Chao Wang,

Juan Li,

Jie Feng

Publication year - 2022

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.03340-21

Subject(s) - klebsiella pneumoniae , antibiotics , carbapenem , microbiology and biotechnology , intensive care medicine , medicine , biology , computational biology , genetics , gene , escherichia coli

Klebsiella pneumoniae carbapenemases (KPCs) are powerfulβ -lactamases that enable Gram-negative pathogens to destroy clinically important carbapenems in antibiotic therapies. In particular, KPC-2 is difficult to detect due to a lack of instrument sensitivity in regular laboratory screens, which leads to misdiagnosis and poor treatment outcomes.

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