Open AccessSecretion, Maturation, and Activity of a Quorum Sensing Peptide (GSP) Inducing Bacteriocin Transcription in Streptococcus gallolyticus
Author(s) -
Anthony Harrington,
Alexis Proutière,
Ryan W. Mull,
Laurence du Merle,
Shaynoor Dramsi,
Yftah TalGan
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03189-20
Subject(s) - bacteriocin , biology , microbiology and biotechnology , lactococcus lactis , bacteria , peptide , antimicrobial , biochemistry , genetics , lactic acid
Streptococcus gallolyticus subsp.gallolyticus is an opportunistic pathogen associated with colorectal cancer (CRC) and endocarditis.S. gallolyticus subsp.gallolyticus utilizes quorum sensing (QS) to regulate the production of a bacteriocin (gallocin) and gain a selective advantage in colonizing the colon. In this article, we report (i) the first structure-activity relationship study of theS. gallolyticus subsp.gallolyticus QS pheromone that regulates gallocin production, (ii) evidence that the active QS pheromone is processed to its mature form by a unique ABC transporter and not processed by an extracellular protease, and (iii) supporting evidence of interspecies interactions between streptococcal pheromones.